The aspirin-ibuprofen interaction in rheumatoid arthritis.

  title={The aspirin-ibuprofen interaction in rheumatoid arthritis.},
  author={David Michael Grennan and Dr. George D. Ferry and Mark Ashworth and Rhonda Kenny and M W B Mackinnon},
  journal={British journal of clinical pharmacology},
  volume={8 5},
1 This was a double-blind crossover trial of ibuprofen and soluble aspirin against each drug alone and against placebo in patients with rheumatoid arthritis. Two dosage regimes were tested. 2 A weak clinical additive effect was demonstrated between soluble aspirin and ibuprofen in patients with rheumatoid arthritis using moderate (1600 mg ibuprofen and 3.6 g aspirin daily) but not low (800 mg ibuprofen and 2.4 g aspirin daily) dosages of both drugs. 3 A significant correlation between clinical… CONTINUE READING

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