The aryl hydrocarbon receptor complex and the control of gene expression.

@article{Beischlag2008TheAH,
  title={The aryl hydrocarbon receptor complex and the control of gene expression.},
  author={Timothy V. Beischlag and J Luis Morales and Brett D. Hollingshead and Gary H. Perdew},
  journal={Critical reviews in eukaryotic gene expression},
  year={2008},
  volume={18 3},
  pages={207-50}
}
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin is almost exclusively mediated through this receptor. However, the key alterations in gene expression that mediate toxicity are poorly understood. It has been established through characterization of AhR-null mice that the AhR has a required physiological function, yet how endogenous… CONTINUE READING
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