The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

@article{Baglole2008TheAH,
  title={The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.},
  author={Carolyn J Baglole and Sanjay B. Maggirwar and Thomas A Gasiewicz and Thomas H Thatcher and Richard P Phipps and Patricia J. Sime},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 43},
  pages={28944-57}
}
Diseases such as chronic obstructive pulmonary disease and lung cancer caused by cigarette smoke affect millions of people worldwide. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that influences responses to certain environmental pollutants such as tobacco smoke. However, the physiological function(s) of the AhR is unknown. Herein we propose that the physiologic role of the AhR is to limit inflammation. We show that lung fibroblasts from AhR(-/-) mice produce a… CONTINUE READING
57 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Sarcoidosis Vasc

  • A. Xaubet, J. Roca-Ferrer, +6 authors C. Picado
  • Diffuse Lung Dis
  • 2004

AhR Regulates Inflammation in Fibroblasts 28956 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • T. L. McLemore, W. C. Hubbard, +5 authors M. R. Boyd
  • Cancer Res
  • 1988

Similar Papers

Loading similar papers…