The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism.

@article{Widerak2006TheAH,
  title={The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism.},
  author={Magdalena Widerak and Christelle Ghoneim and Michel Dumontier and Monique Quesne and Marie Th{\'e}r{\`e}se Corvol and Jean-François Savouret},
  journal={Biochimie},
  year={2006},
  volume={88 3-4},
  pages={
          387-97
        }
}
Aryl hydrocarbon receptor (AhR) ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or benzo(a)pyrene interfere with hormonal regulatory pathways, leading to endocrine disruption. Notably, the activated AhR exerts complex effects on estrogens and retinoids at both levels of their metabolism and regulation of cognate genes. Our current investigation of these AhR effects revealed the TCDD-dependent activation of a subset of retinoid-dependent genes (tissue-transglutaminase, IGF binding… CONTINUE READING
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