The aryl hydrocarbon receptor–cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly

@article{Ohashi2018TheAH,
  title={The aryl hydrocarbon receptor–cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly},
  author={Hirofumi Ohashi and Kazane Nishioka and Syo Nakajima and Sulyi Kim and Ryosuke Suzuki and Hideki Aizaki and Masayoshi Fukasawa and Shinji Kamisuki and Fumio Sugawara and Naoko Ohtani and Masamichi Muramatsu and Takaji Wakita and Koichi Watashi},
  journal={The Journal of Biological Chemistry},
  year={2018},
  volume={293},
  pages={19559 - 19571}
}
Viruses hijack and modify host cell functions to maximize viral proliferation. Hepatitis C virus (HCV) reorganizes host cell metabolism to produce specialized membrane structures and to modify organelles such as double-membrane vesicles and enlarged lipid droplets (LDs), thereby enabling virus replication and assembly. However, the molecular bases of these host–HCV interactions are largely unknown. Here, using a chemical screen, we demonstrate that the benzamide derivative flutamide reduces the… Expand
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