The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

@article{Rothhammer2019TheAH,
  title={The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease},
  author={Veit Rothhammer and Francisco J. Quintana},
  journal={Nature Reviews Immunology},
  year={2019},
  volume={19},
  pages={184-197}
}
The environment, diet, microbiota and body’s metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. In this Review, we… CONTINUE READING
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