The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals

@article{Larue2008TheAA,
  title={The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals},
  author={Rebecca S Larue and Stef{\'a}n Ragnar J{\'o}nsson and Kevin A. T. Silverstein and Mathieu Lajoie and Denis Bertrand and Nadia El-Mabrouk and Isidro H{\"o}tzel and Valgerdur Andr{\'e}sdŏttir and Timothy P. L. Smith and Reuben S Harris},
  journal={BMC Molecular Biology},
  year={2008},
  volume={9},
  pages={104 - 104}
}
APOBEC3 (A3) proteins deaminate DNA cytosines and block the replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one or two conserved zinc-coordinating motifs (Z1, Z2 or Z3). The presence of one A3 gene in mice (Z2–Z3) and seven in humans, A3A-H (Z1a, Z2a-Z1b, Z2b, Z2c-Z2d, Z2e-Z2f, Z2g-Z1c, Z3), suggests extraordinary evolutionary flexibility. To gain insights into the mechanism and timing of A3 gene expansion and into the functional modularity of these genes… CONTINUE READING