The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens.

@article{Fritz2004TheAA,
  title={The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens.},
  author={J{\"o}rg Hermann Fritz and Sylvia Brunner and Max L. Birnstiel and Michael Buschle and Alexander von Gabain and Frank Mattner and Wolfgang Zauner},
  journal={Vaccine},
  year={2004},
  volume={22 25-26},
  pages={3274-84}
}
Cationic antimicrobial peptides (CAMPs) are active defence components of the innate immune system. Several artificial CAMPs have been designed as antibiotic peptide therapeutics, but none have been reported to exert adjuvant activity in animal models. Here we show for the first time that an artificial CAMP, KLKLLLLLKLK (KLKL5KLK), is a potent inducer of adaptive immunity to co-injected antigens in vivo. High levels of antigen-specific antibodies were obtained after co-injection of KLKL5KLK with… CONTINUE READING
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