The art of gene therapy for glioma: a review of the challenging road to the bedside.

@article{Tobias2013TheAO,
  title={The art of gene therapy for glioma: a review of the challenging road to the bedside.},
  author={Alex L. Tobias and Atique U. Ahmed and Kyung Sub Moon and Maciej S. Lesniak},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2013},
  volume={84 2},
  pages={213-22}
}
Glioblastoma multiforme (GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy. Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths. To date, gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials, but has failed… CONTINUE READING
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