The art and design of genetic screens: Drosophila melanogaster

  title={The art and design of genetic screens: Drosophila melanogaster},
  author={Daniel St Johnston},
  journal={Nature Reviews Genetics},
Key Points The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Although traditional genetic screens, such as zygotic lethal screens, have been useful for identifying the genes that act early in fly development, more sophisticated and versatile screens have been developed. Modifier screens, in which genes are identified by their ability to alter the phenotype of flies… 

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