The art and design of genetic screens: Drosophila melanogaster

@article{Johnston2002TheAA,
  title={The art and design of genetic screens: Drosophila melanogaster},
  author={D. St Johnston},
  journal={Nature Reviews Genetics},
  year={2002},
  volume={3},
  pages={176-188}
}
The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devised to circumvent this problem: modifier screens, for example, have been invaluable for elucidating… CONTINUE READING
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