The art and design of functional metagenomic screens.

Abstract

This article summarizes general design principles for functional metagenomics. The focus is on Escherichia coli as an expression host, although alternative host-vector systems are discussed in relation to optimizing gene recovery in activity-based screens. Examples of DNA isolation and enrichment approaches, library construction and phenotypic read-out are… (More)
DOI: 10.1016/j.copbio.2011.02.010

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@article{Taupp2011TheAA, title={The art and design of functional metagenomic screens.}, author={Marcus Taupp and Keith Mewis and Steven J. Hallam}, journal={Current opinion in biotechnology}, year={2011}, volume={22 3}, pages={465-72} }