The arrhythmogenic transient inward current iTI and related contraction in isolated guinea-pig ventricular myocytes.

@article{Fedida1987TheAT,
  title={The arrhythmogenic transient inward current iTI and related contraction in isolated guinea-pig ventricular myocytes.},
  author={D Fedida and Denis Noble and Andrew C. Rankin and Angela J Spindler},
  journal={The Journal of physiology},
  year={1987},
  volume={392},
  pages={523-42}
}
1. The arrhythmogenic transient inward current, iTI, and contractions were recorded in isolated guinea-pig ventricular myocytes, after exposure to strophanthidin or low external K+ (0.5 mM), using a single-microelectrode voltage-clamp technique and an optical measure of contraction. 2. The inward current, iTI, and after-contraction occurred on repolarization after a depolarizing pre-pulse. Longer pre-pulses to more positive potentials increased the size and reduced the latency of iTI… CONTINUE READING