The arrhythmogenic actions of histamine on human atrial fibers.

  title={The arrhythmogenic actions of histamine on human atrial fibers.},
  author={Rafael Levi and James R. Malm and Frederick O. Bowman and Michael R. Rosen},
  journal={Circulation research},
  volume={49 2},
We used standard microelectrode techniques to study the effects of histamine on right atrial tissues from patients undergoing corrective cardiac surgery. In the 10(-6) to 10(-4) M range, histamine increased maximum diastolic potential, action potential amplitude, and automaticity. In some preparations, histamine also induced delayed afterdepolarizations and triggered activity. The potency of histamine in increasing automaticity was about 10 times less than that of epinephrine. Propranolol (2 x… CONTINUE READING