The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice.

@article{Eshet2004TheAI,
  title={The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice.},
  author={R. Eshet and G. Maor and T Ben Ari and M Ben Eliezer and Galia Gat-Yablonski and M. Phillip},
  journal={The Journal of endocrinology},
  year={2004},
  volume={182 1},
  pages={
          165-72
        }
}
Sex hormones may influence longitudinal growth, either indirectly, by affecting the growth-hormone-insulin-like growth factor I (IGF-I) axis, or directly, by affecting changes within the epiphyseal growth plate (EGP). The aim of the present study was to investigate the effects of letrozole, an aromatase inhibitor, on longitudinal growth and changes in the EGP in vivo. Eighteen peripubertal male mice were divided into three groups. The first group was killed at baseline, the second was injected… CONTINUE READING

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