The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.

@article{Stratakis1998TheAE,
  title={The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.},
  author={Constantine A. Stratakis and Alessandra Vottero and Angela M. H. Brodie and Lawrence S. Kirschner and David D. Deatkine and Q. Lu and Wei Yue and Constantine S Mitsiades and Armando W Flor and George P. Chrousos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 4},
  pages={
          1348-57
        }
}
Increased extraglandular aromatization has been reported as the cause of familial gynecomastia. We studied a kindred with aromatase excess inherited in an autosomal dominant manner, in which affected males had heterosexual precocity and/or gynecomastia, and affected females had isosexual precocity and/or macromastia. The propositus was a 9-yr-old boy with gynecomastia. His 7.5-yr-old sister had precocious puberty, and their father and paternal grandmother had peripubertal gynecomastia and… 

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