The armadillo protein p0071 regulates Rho signalling during cytokinesis

@article{Wolf2006TheAP,
  title={The armadillo protein p0071 regulates Rho signalling during cytokinesis},
  author={Annika Wolf and Ren{\'e} Keil and Oliver G{\"o}tzl and A. Mun and K. Schwarze and M. Lederer and S. H{\"u}ttelmaier and M. Hatzfeld},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={1432-1440}
}
Cytokinesis requires the spatio-temporal coordination of cell-cycle control and cytoskeletal reorganization. Members of the Rho-family of GTPases are crucial regulators of this process and assembly of the contractile ring depends on local activation of Rho signalling. Here, we show that the armadillo protein p0071, unlike its relative p120ctn, is localized at the midbody during cytokinesis and is essential for cell division. Both knockdown and overexpression of p0071 interfered with normal cell… Expand
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