The arithmetic of centrosome biogenesis

@article{Delattre2004TheAO,
  title={The arithmetic of centrosome biogenesis},
  author={M. Delattre and P. G{\"o}nczy},
  journal={Journal of Cell Science},
  year={2004},
  volume={117},
  pages={1619 - 1630}
}
How do cells regulate centrosome number? A canonical duplication cycle generates two centrosomes from one in most proliferating cells. Centrioles are key to this process, and molecules such as centrins, SAS-4 and ZYG-1 govern daughter centriole formation. Cdk2 activity probably couples centrosome duplication with the S phase, and a licensing mechanism appears to limit centrosome duplication to once per cell cycle. However, such mechanisms must be altered in some cells – for example… Expand
Centrosome inheritance after fertilization and nuclear transfer in mammals.
TLDR
Questions remain about the faithful reprogramming of centrosomes in cloned mammals and its consequences for embryo development, and the fate and functions ofCentrosome components in nuclear transfer embryos are being investigated by using molecular imaging ofcentrosome proteins labeled with specific markers including green fluorescent protein (GFP). Expand
The Centrosome
Centrosomes are conserved microtubule-based organelles that are essential for animal development. In this chapter, we highlight key centrosomal proteins and describe the centrosome in the context ofExpand
Centrosome duplication: of rules and licenses.
  • E. Nigg
  • Biology, Medicine
  • Trends in cell biology
  • 2007
TLDR
Genetic and structural studies concur to delineate a centriole assembly pathway in Caenorhabditis elegans and the protease Separase, previously known to trigger sister chromatid separation, has been implicated in a licensing mechanism that restricts centrosome duplication to a single occurrence per cell cycle. Expand
Overexpressing Centriole-Replication Proteins In Vivo Induces Centriole Overduplication and De Novo Formation
TLDR
Overexpressing the three proteins known to be required for centriole replication in Drosophila—DSas-6, DSas-4, and Sak can induce the formation of extra centrioles in some tissues but not others, suggesting that centRIole replication is regulated differently in different tissues. Expand
Controlling centrosome number: licenses and blocks.
TLDR
It is proposed that the engagement of centrioles with each other normally blocks centrosome re-duplication, and that disengagement ofcentrioles from each other at the end of mitosis licenses them for duplication in the subsequent cell cycle. Expand
Analysis of centriole elimination during C. elegans oogenesis
TLDR
It is established that centrioles are eliminated during the diplotene stage of the meiotic cell cycle, and it is demonstrated that the germ cell karyotype is important for timely centriole elimination. Expand
Centrosome duplication proceeds during mimosine‐induced G1 cell cycle arrest
TLDR
A model is suggested, which predicts that entry into S‐phase and the rise in Cdk2 activity associated with this transition are not absolutely required to initiate centrosome duplication, but rather, serve to entrain the centrosomes reproduction cycle with cell cycle progression. Expand
Functional characterization of the SAS-4-related protein CPAP in centrosome biology of human cells
TLDR
Important insights are gained into the functions of CPAP at the centrosome and a novel control mechanism of centriole length is identified, relevant for a better understanding of how centrosomes function in the progression of cancer and other diseases. Expand
Asymmetric localization of the CDC25B phosphatase to the mother centrosome during interphase
TLDR
This study reports that CDC25B, along with CHK1, CDK1 and WEE1, localise asymmetrically around the mother centrosome from S to G2-phases, and gradually become evenly distributed to the two centrosomes by late G2 phase, concomitant with centrosom maturation. Expand
Centrosome biogenesis continues in the absence of microtubules during prolonged S‐phase arrest
TLDR
The number of centrosomes that assemble following colcemid washout increases with duration of S‐phase arrest, even though the number of nuclear‐associated foci or pre‐existing centrosome numbers does not increase, which suggests that during S‐ phase, a cryptic generative event occurs repeatedly, even in the absence of new triplet microtubule assembly. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 135 REFERENCES
Centrin-2 Is Required for Centriole Duplication in Mammalian Cells
TLDR
A requirement for centrin in centriole duplication is demonstrated and it is demonstrated that centrioles play a role in organizing spindle pole morphology and in the completion of cytokinesis. Expand
The Apparent Linkage between Centriole Replication and the S Phase of the Cell Cycle
TLDR
Experimental evidence underlying the belief that centriole duplication is linked with the entry into, or progression through S phase is reviewed. Expand
De novo formation of centrosomes in vertebrate cells arrested during S phase
TLDR
It is found that when centrosomes are completely destroyed by laser microsurgery in CHO cells arrested in S phase by hydroxyurea, new centrioles form by de novo assembly. Expand
Centrosome number is controlled by a centrosome-intrinsic block to reduplication
TLDR
It is found that human primary cells have tight control over centrosome number during prolonged S-phase arrest and that this control is partially abrogated in transformed cells, suggesting a link between the control of centrosomes duplication and maintenance of genomic stability. Expand
Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation
  • T. Murphy
  • Biology, Medicine
  • Journal of Cell Science
  • 2003
TLDR
Surprisingly, many mutant cells are able to organize pseudo-bipolar spindles and execute a normal anaphase in the presence of extra functional centrosomes, suggesting that additional SCF targets regulate the centrosome duplication pathway. Expand
The coordination of centrosome reproduction with nuclear events during the cell cycle.
TLDR
The sequential activation and inactivation of one or more of the cyclin-dependent kinases (Cdks) could function as the cytoplasmic mechanism that coordinately drives centrosome duplication and nuclear events in the cell cycle. Expand
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
TLDR
The data suggest that CP110 is a physiological centrosomal CDK target that promotes centrosome duplication, and its deregulation may contribute to genomic instability. Expand
Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression.
TLDR
It is reported that the expression in HeLa cells of the C terminus of AKAP450, which contains the centrosome-targeting domain ofAKAP450 but not its coiled-coil domains or binding sites for signaling molecules, leads to the displacement of the endogenous centrosomal AKAP 450 without removing centriolar or pericentrosomal components such as centrin, gamma-tubulin, or percentrin. Expand
The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote
TLDR
The repeated reproduction of centrosomes during S phase arrest points to the existence of a necessary “licensing” event that restores this component to daughter centrosome During S phase, preparing them to reproduce in the next cell cycle. Expand
Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control
TLDR
It is concluded that centrosome reproduction in sea urchin zygotes is not controlled by the accumulation of cyclin proteins or the synthesis of centrosomes- specific proteins at each cell cycle, and the results indicate thatCentrosomal and nuclear events are regulated by separate pathways. Expand
...
1
2
3
4
5
...