The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

@article{Secher2014TheAN,
  title={The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.},
  author={Anna Secher and Jacob Jelsing and Arian F Baquero and Jacob Hecksher-S{\o}rensen and Michael A Cowley and Louise S Dalb{\o}ge and Gitte Hansen and Kevin L. Grove and Charles Pyke and Kirsten Raun and Lauge Sch{\"a}ffer and Mads Tang-Christensen and Saurabh Singh Verma and Brent M Witgen and Niels Vrang and Lotte Bjerre Knudsen},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 10},
  pages={
          4473-88
        }
}
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2 diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully understood how liraglutide induces weight loss or to what degree liraglutide acts directly in the brain. Here, we determined that liraglutide does not activate GLP-1-producing neurons in the hindbrain, and liraglutide-dependent body weight reduction in rats was independent of GLP-1 receptors (GLP-1Rs) in the… CONTINUE READING

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