The architecture of respiratory complex I

@article{Efremov2010TheAO,
  title={The architecture of respiratory complex I},
  author={Rouslan Efremov and Rozbeh Baradaran and Leonid A. Sazanov},
  journal={Nature},
  year={2010},
  volume={465},
  pages={441-445}
}
Complex I is the first enzyme of the respiratory chain and has a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determined the structure of its hydrophilic domain previously. Here, we report the α-helical structure of the membrane domain of complex I from Escherichia coli at 3.9 Å resolution. The… CONTINUE READING
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