The architecture of active zone material at the frog's neuromuscular junction

@article{Harlow2001TheAO,
  title={The architecture of active zone material at the frog's neuromuscular junction},
  author={Mark Harlow and David B Ress and Arne Stoschek and Robert M. Marshall and Uel Jackson McMahan},
  journal={Nature},
  year={2001},
  volume={409},
  pages={479-484}
}
Active zone material at the nervous system's synapses is situated next to synaptic vesicles that are docked at the presynaptic plasma membrane, and calcium channels that are anchored in the membrane. Here we use electron microscope tomography to show the arrangement and associations of structural components of this compact organelle at a model synapse, the frog's neuromuscular junction. Our findings indicate that the active zone material helps to dock the vesicles and anchor the channels, and… CONTINUE READING
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