The arachidonic acid effect on platelet nitric oxide level.

@article{Signorello2009TheAA,
  title={The arachidonic acid effect on platelet nitric oxide level.},
  author={M. Signorello and Alessia Segantin and G. Leoncini},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1791 11},
  pages={
          1084-92
        }
}
Arachidonic acid can act as a second messenger regulating many cellular processes among which is nitric oxide (NO) formation. The aim of the present study was to investigate the molecular mechanisms involved in the arachidonic acid effect on platelet NO level. Thus NO, cGMP and superoxide anion level, the phosphorylation status of nitric oxide synthase, the protein kinase C (PKC), and NADPH oxidase activation were measured. Arachidonic acid dose-dependently reduced NO and cGMP level. The… Expand
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