The arachidonic acid-LTB4-BLT2 pathway enhances human B-CLL aggressiveness.

@article{Guriec2014TheAA,
  title={The arachidonic acid-LTB4-BLT2 pathway enhances human B-CLL aggressiveness.},
  author={Nathalie Guriec and Catherine Le Jossic-Corcos and Brigitte Simon and Jean-Christophe Ianotto and Adrian Tempescul and Yvonne Dr{\'e}ano and J. -P. Sala{\"u}n and Christian Berthou and Laurent Corcos},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 11},
  pages={
          2096-105
        }
}
Deregulation of the oxidative cascade of poly-unsaturated fatty acids (PUFAs) has been associated with several cancers, including chronic lymphocytic leukemia (B-CLL). Leukotriene B4 (LTB4), a metabolite of arachidonic acid (AA), is produced by B-CLL and contributes to their survival. The aim of the present study was to analyze the activity of the oxidative cascade of PUFAs in B-CLL. Purified B cells from patients and normal B CD5 positive cells were subjected to flow cytometry, Western-blot… CONTINUE READING