The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages.

@article{Seo2001TheAE,
  title={The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages.},
  author={Won G. Seo and H O Pae and G S Oh and Nam Yi Kim and Tae Oh Kwon and Min Kyung Shin and Kyu Yun Chai and Hun Taeg Chung},
  journal={Journal of ethnopharmacology},
  year={2001},
  volume={76 1},
  pages={119-23}
}
In the present study, we examined the effects of the aqueous extract of Rhodiola sachalinensis root (RSE) on the expression of inducible nitric oxide (NO) synthase (iNOS) gene in RAW264.7 macrophages. RSE synergistically increased NO synthesis in interferon-gamma-primed macrophages. Reverse transcriptase polymerase chain reaction and Northern blotting analysis revealed that RSE may provide a second triggering signal for the synergistic induction of iNOS mRNA expression. Thus, iNOS-mediated NO… CONTINUE READING

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