The application of the restriction site mutation assay to the study of the induction of mutations in the tissues of rodents.


The restriction site mutation (RSM) assay has been developed as a methodology for the study of base changes induced in restriction enzyme recognition sequences. In principle, the RSM methodology may be used to the study mutation induction in any organ, of any species, for which DNA sequence information is available. This paper describes the analysis of the… (More)


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