The application of mass spectrometry to membrane proteomics

  title={The application of mass spectrometry to membrane proteomics},
  author={Christine C. Wu and John R. Yates},
  journal={Nature Biotechnology},
Membrane proteins perform some of the most important functions in the cell, including the regulation of cell signaling through surface receptors, cell–cell interactions, and the intracellular compartmentalization of organelles. Recent developments in proteomic strategies have focused on the inclusion of membrane proteins in high-throughput analyses. While slow and steady progress continues to be made in gel-based technologies, significant advances have been reported in non-gel shotgun methods… CONTINUE READING

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