The application of glycosphingolipid arrays to autoantibody detection in neuroimmunological disorders.

@article{GalbanHorcajo2014TheAO,
  title={The application of glycosphingolipid arrays to autoantibody detection in neuroimmunological disorders.},
  author={Francesc Galban-Horcajo and Susan K. Halstead and Rhona McGonigal and Hugh John Willison},
  journal={Current opinion in chemical biology},
  year={2014},
  volume={18},
  pages={78-86}
}
Humans with autoimmune peripheral neuropathies frequently harbour serum antibodies to single glycosphingolipids, especially gangliosides. Recently it has been appreciated that glycolipid and lipid complexes, formed from two or more individual species, can interact to create molecular shapes capable of being recognised by these autoantibodies whilst not binding to the single individuals. As a result of this, novel autoantibody targets have been identified. This newly termed 'combinatorial… CONTINUE READING

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