The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy

@inproceedings{Hadjivassiliou2010TheAO,
  title={The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy},
  author={George Hadjivassiliou and L. Martinian and Waney Squier and Ingmar Blumcke and E. Aronica and Sanjay M. Sisodiya and Maria Thom},
  booktitle={Acta Neuropathologica},
  year={2010}
}
The diagnostic criteria for focal cortical dysplasia type I (FCD I) remain to be well and consistently defined. Cortical layer-specific markers (CLM) provide a potential tool for the objective assessment of any dyslamination. We studied expression patterns of recognised CLM using immunohistochemistry for N200, ER81, Otx1, Map1b (subsets of V/VI projection neurones), Pax6, Tbr1, Tbr2 (differentially expressed in cortical neurones from intermediate progenitor cells), Cux 1 (outer cortical layers… CONTINUE READING
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