The application of biofilm science to the study and control of chronic bacterial infections.

  title={The application of biofilm science to the study and control of chronic bacterial infections.},
  author={William J. Costerton and Richard H Veeh and Mark E. Shirtliff and Mark E Pasmore and Christopher Post and G. Ehrlich},
  journal={The Journal of clinical investigation},
  volume={112 10},
Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science… CONTINUE READING
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