The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

@article{Olinga2001TheAO,
  title={The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.},
  author={Peter Olinga and I H Hof and Marjolijn T. Merema and M Smit and Marina H de Jager and Pieter Jacob Swart and Maarten J. H. Slooff and D K Meijer and Geny M M Groothuis},
  journal={Journal of pharmacological and toxicological methods},
  year={2001},
  volume={45 1},
  pages={
          55-63
        }
}
In the present study we investigated the applicability of the liver slice model to study mechanisms of drug uptake. Four model compounds were investigated that enter hepatocytes via entirely different membrane transport mechanisms. Rhodamine B (RB), which enters hepatocytes by passive diffusion, was homogeneously distributed throughout the rat liver slice (250 microm thickness) within 5 min, indicating that the penetration rate into the slice and the diffusion rate into the cells are rapid. In… CONTINUE READING

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