The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia.

@article{Hillebrand2006TheAS,
  title={The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia.},
  author={Jacquelien J G Hillebrand and Anton Heinsbroek and Martien J. Kas and Roger A H Adan},
  journal={Journal of molecular endocrinology},
  year={2006},
  volume={36 1},
  pages={153-62}
}
Biochemical, genetic and imaging studies support the involvement of the serotonin (5-HT) system in anorexia nervosa. Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa, and combines scheduled feeding with voluntary running wheel activity (RWA). We investigated the effect of d-fenfluramine (d-FEN) treatment on development and propagation of ABA. d-FEN is an appetite suppressant and acts on 5-HT(2C) receptors that are located on pro-opiomelanocortin (POMC) neurons in… CONTINUE READING
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