The appearance of NPY and VIP in sympathetic neuroblasts and subsequent alterations in their expression.

  title={The appearance of NPY and VIP in sympathetic neuroblasts and subsequent alterations in their expression.},
  author={Sian Tyrrell and Story C. Landis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 7},
Mature sympathetic neurons contain one or more neuropeptides in addition to a classical neurotransmitter. We compared the development of two peptides, neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP), in rat superior cervical (SCG) and stellate ganglia. NPY immunoreactivity (-IR) was first detected at embryonic day (E) 12.5. It was of similar immunofluorescence intensity in almost all tyrosine hydroxylase (TH)-IR cells. In contrast, VIP-IR, of variable fluorescence intensity… CONTINUE READING


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