The appearance of DNase I hypersensitive sites at the 5' end of the late SV40 genes is correlated with the transcriptional switch.

@article{Crmisi1981TheAO,
  title={The appearance of DNase I hypersensitive sites at the 5' end of the late SV40 genes is correlated with the transcriptional switch.},
  author={C. Cr{\'e}misi},
  journal={Nucleic acids research},
  year={1981},
  volume={9 22},
  pages={
          5949-64
        }
}
  • C. Crémisi
  • Published 1981
  • Biology, Medicine
  • Nucleic acids research
  • DNase I digestion of the SV40 nuclear chromosome late in infection reveals three hypersensitive sites on the late side of the Bg1 I site. Two of these sites at bp 370, 270 correspond to the 5' side of the late transcripts while the third at bp 190, to a region that is required for early transcription. Early in infection, as well as in an SV40 transformed cell line and a T-Ag negative revertant (deleted in the coding region for T-Ag) only one of these sites is present - the one associated with… CONTINUE READING
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