The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spin-trapping.

@article{Buettner1980TheAP,
  title={The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spin-trapping.},
  author={Garry R Buettner and Larry W. Oberley},
  journal={FEBS letters},
  year={1980},
  volume={121 1},
  pages={161-4}
}
Hematoporphyrin is known to have photodynamic properties. The exposure of biomolecules or cells to hematoporphyrin and visible light can result in damage [l] and can even be lethal [2]. This inactivating effect appears to be greater in cancer cells than in corresponding normal cells [3]. This is thought to be due in part to the greater acc~ulation of hematoporphyrin in malignant tissue than in most other tissues 14-71. There is evidence that the cytotoxic action of hematoporphyrin and light is… CONTINUE READING

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Buil

  • G. B. Grhdey, R. FieL, K. R. Weishaupt, G. Boyle-D.
  • John Hopkins Hosp .
  • 1960

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