The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1.

@article{Li2013TheAO,
  title={The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1.},
  author={Wenjun Li and Minhong Zhang and Lei Xu and Danmiao Lin and Shao Xi Cai and Fei Zou},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2013},
  volume={65 7-8},
  pages={1073-81}
}
Cis-diamminedichloroplatinum (II) (cisplatin) is one of the most active antitumor agents used in human chemotherapy of non-small cell lung cancer. Cisplatin forms crosslinked DNA adducts and its cytotoxicity has been shown to be mediated by propagation of DNA damage recognition signals to downstream pathways prompting apoptosis. The steps involved in the process include changes in Ca(2+) signaling with dysregulated tumor cell turn-over. Stromal interaction molecules 1 (STIM1), as one of the… CONTINUE READING
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