The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.

@article{GonzlezPolo2005TheAP,
  title={The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.},
  author={Rosa-Ana Gonz{\'a}lez-Polo and Patricia Boya and Anne-Laure Pauleau and Abdelali Jalil and Nathanael Larochette and Sylvie Souqu{\`e}re and E L Eskelinen and G{\'e}rard Pierron and Paul Saftig and Guido Kroemer},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 14},
  pages={3091-102}
}
Autophagic cell death is morphologically characterized by an accumulation of autophagic vacuoles. Here, we show that inactivation of LAMP2 by RNA interference or by homologous recombination leads to autophagic vacuolization in nutrient-depleted cells. Cells that lack LAMP2 expression showed an enhanced accumulation of vacuoles carrying the marker LC3, yet a decreased colocalization of LC3 and lysosomes, suggesting that the fusion between autophagic vacuoles and lysosomes was inhibited. While a… CONTINUE READING

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