The apomorphine test: a biological marker for heroin dependence disorder?

  title={The apomorphine test: a biological marker for heroin dependence disorder?},
  author={Jos{\'e} Guardia and Miguel Casas and Gemma Prat and Joan Trujols and Lidia Segura and M. S{\'a}nchez-Turet},
  journal={Addiction Biology},
This experimental study was conducted in the inpatient detoxification addictive behavior unit of the Sant Pau Hospital in Barcelona and included 22 healthy subjects (HS) and 42 intravenous heroin‐dependent subjects (HDS). Apomorphine‐induced yawning rates were investigated in three different groups; heroin‐dependent patients stabilized on d‐propoxiphene, heroin‐dependent patients recently withdrawn from d‐propoxiphene and normal controls. Yawning responses were recorded continuously by… 
Changes in plasma taurine concentration during a period of heroin detoxification
Taurine is one of the most abundant sulpho-amino acids in the body. Hypertaurinemia has already been reported following different stress states. A previous study demonstrated a significant increase
The Many Faces of Apomorphine: Lessons from the Past and Challenges for the Future
The history of apomorphine, from its earliest empirical use, to its synthesis, pharmacological development, and numerous indications in human and veterinary medicine, in light of its most recent uses and newest challenges, is traced.
New tricks for an old dog: A repurposing approach of apomorphine
Apomorphine may play a role in neurological diseases like restless legs syndrome, Huntington’s chorea, amyotrophic lateral sclerosis, Alzheimer's disease and disorders of consciousness, but also in sexual disorders, neuroleptic malignant malignant(‐like) syndrome and cancer.
Psychotic Symptoms Associated with the use of Dopaminergic Drugs, in Patients with Cocaine Dependence or Abuse
Few cases have been described, which suggests that the appearance of these symptoms is infrequent, and the risk of psychotic symptoms seems to be acceptable if the authors compare it with the benefits for the patients but a closer monitoring appears to be advisable.
Effects of the Aqueous and Methanol Extracts of Alchornea Laxiflora in Rodent Models of Experimental Psychosis
The study investigated the median lethal dose and the effects of the aqueous and methanol extracts of Alchornea laxiflora in two mouse models of experimental psychosis, the apomorphine-induced
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Ebselen, chelerythrine and apomorphine complement the armamentarium of compounds to explore the role of glutaminase in disease and it is noteworthy that the affinity of ebselen for glutaminases is more potent than any other activity yet described.
La apomorfina actua sobre receptores postsinapticos hipersensibles por la abstinencia alcoholica y no sobre autoreceptores inhibiendo the liberacion of Dopamina, dado that la hipersENSibilidad en the abst inencia se debe a the inhibicion of the liberación oficial oficial.


The apomorphine test in heroin addicts.
Results showed that subcutaneous apomorphine administration induced a greater number of yawns in the group of heroin addicts as compared with the groupof healthy volunteers, suggesting that heroin addicts present an enhanced sensitivity of the dopamine nuerotransmitter system.
Apomorphine in the evaluation of dopaminergic function in man
  • S. Lal
  • Medicine, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1988
The development of a simple polygraphic method to monitor the yawning response to Apo may facilitate clinical studies on the basic physiology of yawning in man and the use of the yawned response as a measure of central DA function in schizophrenia and other clinical disorders.
Low-dose quinpirole ontogenically sensitizes to quinpirole-induced yawning in rats
It is demonstrated that quinPirole receptors are sensitized by a low dose of quinpirole, 60-fold lower than previously shown, and suggested that sensitized receptors are of the DA D3 subclass.
Apomorphine-induced penile erection and yawning: site of action in brain
The present results suggest that the PVN is the brain area where D2 DA agonists act to induce penile erection and yawning in rats, and for the first time a possible involvement of the incerto-hypothalamic DA system in the expression of penile erections and yawns is suggested.
The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity.
The suitability of elicitation of the combined syndrome of yawning plus penile erections as useful behavioural model for dopamine autoreceptor agonists is discussed.
Striatal Dopaminergic D2 Receptor Density Measured by [123I]Iodobenzamide SPECT in the Prediction of Treatment Outcome of Alcohol-Dependent Patients
OBJECTIVE: The authors’ goal was to study striatal dopaminergic dopamine 2 (D2) receptors as a biological marker of early relapse in detoxified alcoholic patients by using [123I]iodobenzamide
Drug addiction as dopamine-dependent associative learning disorder.
Addictive drugs are the expression of the excessive control over behaviour acquired by drug-related stimuli as a result of abnormal associative learning following repeated stimulation of dopamine transmission in the nucleus accumbens shell.
Estrogens antagonize apomorphine-induced yawning in rats.
The results suggest that both endogenous or exogenously administered estrogens induce subsensitivity of the DA receptors mediating yawning in rats.
Apomorphine test in the assessment of parkinsonian patients: a meta-analysis.