The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia.

@article{Buzello2003TheAE,
  title={The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia.},
  author={Moriz Buzello and Johannes T{\"o}rnig and Joerg Faulhaber and Heimo Ehmke and Eberhard Ritz and Kerstin Amann},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 2},
  pages={311-6}
}
Rodents do not develop spontaneous atherosclerosis. Currently, there is no good animal model to study the effect of uremia on atherosclerosis. This study evaluated whether apolipoprotein E knockout (Apoe-/-) mice are useful to study the effect of renal dysfunction on cardiovascular risk. Apoe-/- mice have decreased serum apolipoprotein E and exhibit lipid abnormalities and atherosclerosis even on a low-cholesterol diet. Ten-wk-old Apoe-/- mice were subtotally nephrectomised (SNX Apoe-/-; n = 8… CONTINUE READING

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