The apolipoprotein E gene, attention, and brain function.

  title={The apolipoprotein E gene, attention, and brain function.},
  author={Raja Parasuraman and Pamela M. Greenwood and Trey P Sunderland},
  volume={16 2},
The epsilon4 allele of the apolipoprotein E (ApoE) gene is associated with alterations in brain function and is a risk factor for Alzheimer's disease (AD). Changes in components of visuospatial attention with ApoE-epsilon4, aging, and AD are described. Healthy middle-aged adults without dementia who have the ApoE-epsilon4 gene show deficits in spatial attention and working memory that are qualitatively similar to those seen in clinically diagnosed AD patients. The findings support an… CONTINUE READING