The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease.

@article{Kessler1997TheAE,
  title={The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease.},
  author={Christine Kessler and Carsten Spitzer and D Stauske and Susan A. Mende and J Stadlm{\"u}ller and R. {\'A}lvarez-Sala Walther and Rainer Rettig},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 11},
  pages={2880-4}
}
The relationship between the apolipoprotein E (apoE) and beta-fibrinogen G/A-455 polymorphisms and cerebrovascular disease (CVD) was examined in the present study. We compared 227 patients with the subtypes of CVD (large-vessel disease, lacunar stroke, cardiac embolism, or undetermined pathomechanisms) with 225 control subjects. The occurrence of apoE isoforms (E2, E3, and E4) and the beta-fibrinogen G/A-455 genotype was determined in these individuals. No differences in apoE polymorphisms or… CONTINUE READING