The apolipoprotein E ɛ4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge

@article{Pomara2008TheAE,
  title={The apolipoprotein E ɛ4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge},
  author={Nunzio Pomara and Kenneth D. Belzer and Raul Silva and Thomas B. Cooper and John J. Sidtis},
  journal={Psychopharmacology},
  year={2008},
  volume={201},
  pages={125-135}
}
The APOE ɛ4 allele, an established genetic risk factor for late-onset Alzheimer’s disease, has been linked to an increased risk for dementia especially in older individuals with HIV-1 infection. This allele has also been associated with increased memory impairment following oral lorazepam challenge in healthy elderly. Lorazepam and other benzodiazepines are widely prescribed in individuals with HIV-1 infection who are at increased risk for cognitive impairment. The aim of this study was to… CONTINUE READING

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