The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.

@article{Chester2003TheAB,
  title={The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.},
  author={Ann Chester and Angelika Somasekaram and Maria Tzimina and A. Jarmuz and Jane Gisbourne and Raymond T O'Keefe and James M Scott and N. Navaratnam},
  journal={The EMBO journal},
  year={2003},
  volume={22 15},
  pages={3971-82}
}
The C to U editing of apolipoprotein B (apoB) mRNA is mediated by a minimal complex composed of an RNA-binding cytidine deaminase (APOBEC1) and a complementing specificity factor (ACF). This editing generates a premature termination codon and a truncated open reading frame. We demonstrate that the APOBEC1-ACF holoenzyme mediates a multifunctional cycle. The atypical APOBEC1 nuclear localization signal is involved in RNA binding and is used to import ACF into the nucleus as cargo. APOBEC1 alone… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…