The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.

@article{Stehle2012TheAO,
  title={The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.},
  author={T. Stehle and Sridhar Sreeramulu and Frank Loehr and Christian Richter and Krishna G Saxena and Hendrik R. A. Jonker and Harald Schwalbe},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 41},
  pages={34569-82}
}
Protein-tyrosine phosphatases (PTPs) and protein-tyrosine kinases co-regulate cellular processes. In pathogenic bacteria, they are frequently exploited to act as key virulence factors for human diseases. Mycobacterium tuberculosis, the causative organism of tuberculosis, secretes a low molecular weight PTP (LMW-PTP), MptpA, which is required for its survival upon infection of host macrophages. Although there is otherwise no sequence similarity of LMW-PTPs to other classes of PTPs, the phosphate… CONTINUE READING

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