The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

@article{Robert1991TheAE,
  title={The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.},
  author={Benjamin Robert and Gary Lyons and B K Simandl and Atsushi Kuroiwa and M. Buckingham},
  journal={Genes & development},
  year={1991},
  volume={5 12B},
  pages={2363-74}
}
We show that expression of the two related chicken homeo box genes, Hox-7 and Hox-8, which is widespread in the lateral mesoderm at early stages, becomes restricted to the mesoderm underlying the apical ectodermal ridge as limbs develop. Expression in the limb bud mesoderm is not maintained in the limbless mutant, which does not form an apical ridge. The mutant can be rescued by grafting normal ectoderm to the limb field. This leads to expression of the two homeo box genes in the mesoderm under… CONTINUE READING

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