The aortic valve microenvironment and its role in calcific aortic valve disease.

@article{Yip2011TheAV,
  title={The aortic valve microenvironment and its role in calcific aortic valve disease.},
  author={Cindy Ying Yin Yip and Craig A. Simmons},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={2011},
  volume={20 3},
  pages={177-82}
}
In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa microenvironment is permissive to pathological development. The cellular microenvironment in the aortic valve is defined by a variety of biomechanical-, biochemical-, and extracellular-mediated factors, some of which are unique to the fibrosa. Growing evidence supports the role of these microenvironmental cues in… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
33 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…