The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism.

@article{Eguchi2001TheAE,
  title={The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism.},
  author={Junichi Eguchi and Yuji Inomata and Keiko Saito},
  journal={Pharmacology, biochemistry, and behavior},
  year={2001},
  volume={68 4},
  pages={677-83}
}
We have previously reported that MCI-225, a selective noradrenaline (NA) reuptake inhibitor with serotonin (5-HT)3 receptor antagonism, shows antidepressant-like properties in experiments using rodents. In this study, we investigated the effect of MCI-225 in anxiety models in comparison with diazepam, ondansetron, maprotiline, imipramine, and trazodone. In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, p.o.), diazepam (1-10 mg/kg, p.o.), and a selective 5-HT3 receptor… CONTINUE READING
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