The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil.

@article{SchmidtMutter1998TheAE,
  title={The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil.},
  author={Catherine Schmidt-Mutter and Laure Pain and Guy Sandner and Serge Gobaille and Michel Maitre},
  journal={European journal of pharmacology},
  year={1998},
  volume={342 1},
  pages={21-7}
}
The effects of gamma-hydroxybutyrate (GHB), a product of gamma-aminobutyric acid (GABA) metabolism which possesses neuromodulatory properties in brain, were investigated in the elevated plus maze in rats. The number of entries and the time spent in the open arms of the maze were increased by GHB (50, 150, 250 mg/kg i.p.). This is classically considered as indicative of an anxiolytic effect of the drug. There was no sedative effect at these doses as measured by the spontaneous locomotor activity… CONTINUE READING
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