The anxiolytic‐like effect of 5‐HT1B receptor ligands in rats: a possible mechanism of action

@article{Chojnackawjcik2005TheAE,
  title={The anxiolytic‐like effect of 5‐HT1B receptor ligands in rats: a possible mechanism of action},
  author={E. Chojnacka-w{\'o}jcik and Aleksandra Kłodzińska and Ewa Tatarczyńska},
  journal={Journal of Pharmacy and Pharmacology},
  year={2005},
  volume={57}
}
We have examined the effect of lesions of 5‐hydroxytryptamine (5‐HT) neurons, produced by p‐chloroamphetamine (p‐CA; 2 times 10 mg kg−1), and the influence of flumazenil (Ro 15–1788, 10 mg kg−1), a benzodiazepine receptor antagonist, on the anxiolytic‐like activity of CP 94253 (5‐propoxy‐3‐(1,2,3,6‐tetrahydro‐4‐pyridinyl)‐1‐H‐pyrrolo[3,2‐b]pyridine), a 5‐HT1B receptor agonist, SB 216641 (N‐[3‐[3‐(dimethylamino)ethoxy]‐4‐methoxyphenyl]‐2′‐methyl‐4′‐(5‐methyl‐1,2,4‐oxadiazol‐3‐yl)‐[1,1′‐biphenyl… 

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