The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A2A adenosine receptor antagonists

@article{Yacoubi2000TheAE,
  title={The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A2A adenosine receptor antagonists},
  author={Malika El Yacoubi and Catherine A. Ledent and Marc Parmentier and Jean Costentin and J. -M. Vaugeois},
  journal={Psychopharmacology},
  year={2000},
  volume={148},
  pages={153-163}
}
Rationale: The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. Objective: Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter of debate. The present study investigated whether the anxiogenic effects of caffeine observed in mice depend on the blockade of A2A receptor. First, the effects induced by the… CONTINUE READING

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