The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse

@article{Shepard2004TheAD,
  title={The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse},
  author={Jack D Shepard and Jennifer M Bossert and Shirley Yan Chen Liu and Yavin Shaham},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={1082-1089}
}
BACKGROUND Brain noradrenaline is involved in footshock stress-induced reinstatement of drug seeking in a rat relapse model. We studied whether yohimbine, an alpha-2 adrenoceptor antagonist that increases noradrenaline release and induces anxiety-like responses in human and nonhuman subjects, would reinstate methamphetamine seeking in rats. METHODS In experiment 1, the effect of yohimbine (1.25-2.5 mg/kg) on reinstatement was compared with that of intermittent footshock (5 min;.2-.6 mA) in… CONTINUE READING
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